Rapid Phage Display Solutions ideal for SLAS: Screening Ligands for Affinity and Selectivity
The identification of high quality, specific, and sensitive affinity reagents, including antibodies, antibody mimics, and peptides, remains a significant challenge in life science research, drug discovery, and diagnostics. Traditional approaches that rely on animal immunization are cumbersome and often prone to batch-to-batch variability. Screening technologies using cellular and organism models such as yeast and bacteria offer massive parallel screening workflows that overcome many of the caveats of traditional approaches, yet can also be restrictive and time consuming. In this Spotlight Presentation, Tango Biosciences will showcase its innovative approach to phage display and how it is transforming the rapid discovery of affinity reagents for challenging antigen detection from research tools through diagnostics and therapeutic applications. We demonstrate the power of this unique approach to screen and optimize novel affinity reagents that detect and distinguish a specific phosphorylated protein target with unprecedented levels of specificity. Next, we show how to discover and characterize peptide ligands to GLP-1 receptor and HIV coat protein. Finally, we introduce a proprietary multi-site discovery technology, called the Avidimer Platform, that offers an accelerated workflow for multimerized monobody, nanobody, and antibody discovery and showcase how it is ideally suited for the development of sandwich assays used in diagnostics and other multi-site binding applications. Together, our flexible phage display solutions combined with world-class phage libraries permit the rapid discovery of diverse affinity reagents that are tailored to fit the needs of any project.
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