Peptide Drug Discovery

High-Throughput Screening for Peptide Therapeutics

High-throughput screening is a proven approach in drug discovery to identify candidate drugs. Tango Biosciences’ phage display platform and custom peptide libraries are ideally suited to rapidly identify initial hits for any target. Our affinity maturation phase can augment binding to maximize affinity and selectivity.

We offer several phage display libraries featuring varying copy number, linear and cyclic peptides, and peptide length, along with custom peptide library solutions to initiate discovery for your next program.

TANGO BIOSciences’ WORKFLOW FOR PEPTIDE DRUG DISCOVERY

WORLD-CLASS PHAGE DISPLAY PEPTIDE LIBRARIES

Linear Peptide Libraries

Length (AA)	Properties	size
8	Randomized with all 20 AAs	1.3 x 10⁹
10	Randomized with all 20 AAs	5.5 x 10¹⁰
12	Randomized with all 20 AAs	1.6 x 10⁹
20	Randomized with all 20 AAs	1.0 x 10¹⁰
20	Uses 15 AAs, omits W, Q, M, K, E	4.0 x 10⁸
10	N-terminus randomized	5.0 x 10⁹
12	N-terminus randomized	1.8 x 10¹⁰
9	High copy number N-term display	1.0 x 10⁹
9	High copy number C-term display	1.0 x 10⁹
7	Protease substrate discovery	2.8 x 10⁸

Cysteine-Constrained Peptide Libraries

Length (AA)	Loop size	sequence	size
10	4	X₂CX₄CX₂	1.6 x 10¹⁰
11	5	X₂CX₅CX₂	1.0 x 10⁹
12	6	X₂CX₆CX₂	2.1 x 10¹⁰
11	7	XCX₇CX	2.1 x 10¹⁰
12	8	XCX₈CX	8.5 x 10⁹
11	9	CX₉C	2.8 x 10⁹
12	10	CX₁₀C	4.2 x 10⁹
11	4-10	X₁₀C	1.8 x 10¹⁰
11	4-8	X₈CX₂	3.6 x 10¹⁰
18	6 stapled α-helix	ααααX₃CX₂ααX₂CX₃	In production
20	6 and 6, dicyclic	ACX₆CX₆CGGGS	In production

X= all 20 amino acids; C= Cysteine; α= fixed amino acids with propensity to form α-helices

Case Study

Tango Biosciences enables peptide and small molecule drug discovery in a single screen

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Peptide Libraries

Download our case study demonstrating how Tango Biosciences’ peptide libraries revealed novel peptide drug candidates.

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