Peptide Drug Discovery

High-Throughput Screening for Peptide Therapeutics

High-throughput screening is a proven approach in drug discovery to identify candidate drugs. Tango Biosciences’ phage display platform and custom peptide libraries are ideally suited to rapidly identify initial hits for any target. Our affinity maturation phase can augment binding to maximize affinity and selectivity.

We offer several phage display libraries featuring varying copy number, linear and cyclic peptides, and peptide length, along with custom peptide library solutions to initiate discovery for your next program.

TANGO BIOSciences’ WORKFLOW FOR PEPTIDE DRUG DISCOVERY

WORLD-CLASS PHAGE DISPLAY PEPTIDE LIBRARIES

Linear Peptide Libraries

Length (AA)Propertiessize
8Randomized with all 20 amino acids1.3 x 109
10Randomized with all 20 amino acids5.5 x 1010
12Randomized with all 20 amino acids1.6 x 109
20Randomized with all 20 amino acids1.0 x 1010
20Uses 15 amino acids, omits W, Q, M, K, E4.0 x 108
10N-terminus randomized with all 20 amino acids5.0 x 109
12N-terminus randomized with all 20 amino acids1.8 x 1010
9High copy number N-terminal display1.0 x 109
9High copy number C-terminal display1.0 x 109
7Protease substrate discovery2.8 x 108

Cysteine-Constrained Peptide Libraries

Length (AA)Loop sizesequencesize
104X2CX4CX21.6 x 1010
115X2CX5CX21.0 x 109
126X2CX6CX22.1 x 1010
117XCX7CX2.1 x 1010
128XCX8CX8.5 x 109
119CX9C2.8 x 109
1210CX10C4.2 x 109
114-10X10C1.8 x 1010
114-8X8CX23.6 x 1010
13VariableX6CX64.2 x 109
186 stapled α-helixααααX3CX2ααX2CX31.6 x 1010
206 and 6, dicyclicACX6CX6CGGGS4.2 x 109
15MacrocyclicCX3CX9C3.5 x 109
15MacrocyclicCX6CX6C3.5 x 109
15MacrocyclicCX9CX3C3.5 x 109
X= all 20 amino acids; C= Cysteine; α= fixed amino acids with propensity to form α-helices

Learn how Tango Biosciences is transforming peptide drug discovery.

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